5-Azacytidine 2’,3’5’-O-triacetate is a useful compound for the treatment and prevention of cancer and disorders related to abnormal cell proliferation, hematological disorders, and myelodysplastic syndromes (MDS). It can be also used to synthesize 2'3'5'triacetyl-5-azacytidine which is a prodrug for azacitidine.?Azacitidine is a FDA-appproved DNA metnyltransferase (DNMT) inhibitor.
參考文獻
Rajendiran, C., et al.:?PCT Int. Appl. (2012), WO?2012135405?A1?20121004; Ziemba, A., et al.:?Chemother Res Pract?965826, 9 (2011); Beisler, J. A., et al.:?J. Carbohyd. Chem?4,?281 (1977)
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