Standards; Pharmaceutical/API Drug Impurities/Metabolites;
應用
Pyrazolo[3,4-d]pyrimidines have a close structural resemblance to the substrates for the enzyme xanthine oxidase, hypoxanthine (6-hydroxypurine) and xanthine (2,6-dihydroxypurine). These compounds are capable of binding to the enzyme and strongly inhibit its activity. They have been studied for their role in the treatment and prophylaxis of hyperuricemia in human patients as well as potential anti-tumor agents.
參考文獻
Massey, V., et al.: J. Biol. Chem., 245, 2837 (1970),
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