Building Blocks; Pharmaceutical/API Drug Impurities/Metabolites;
應用
Des[2’-(1H-tetrazol-5-yl)] 2-Cyanolosartan carboxaldehyde is a derivative of Losartan carboxaldehyde (L470505). Des[2’-(1H-tetrazol-5-yl)] 2-Cyanolosartan carboxaldehyde is also used as reagent to synthesize Losartan Potassium (L470500), a an angiotensin II antagonist and is commonly used to significantly reduce risk of new onset atrial fibrillation and associated stroke in high-risk patients.
參考文獻
Madasu, S., et al.: Org. Process Res. Dev., 16, 2025 (2012); Pitt, B., et al.: The Lancet, 355, 1582 (2000); Wachtell, K., et al.: J. Am. Coll. Cardiol., 45, 712 (2005)
滬ICP備17019645號
400-821-0725
