5-Ethynyl-2тАЩ-deoxyuridine is an extensively used nucleoside analog used as a probe for DNA synthesis. 5-Ethynyl-2тАЩ-deoxyuridine is known as an toxic anti-metabolite, which potentially causes DNA instabiliy, necrosis and cell-cycle arrest, therefore it is often used for short-term DNA synthesis in tissue culture and living organisms where prolonged cell survival is not required.
參考文獻
Neef, A.B., et al.: P. Natl. Acad. Sci.., 108, 20404 (2011); Gristwood, T., et al.: Nucleic. Acids. Rsch., 40, 5487 (2012);
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