Standards; Pharmaceutical/API Drug Impurities/Metabolites;
應用
Loperamide oxide (LOPOX) is a prodrug of Loperamide (LOP). It is concluded that Loperamide oxide administered intraluminally is reduced to Loperamide and has the same antisecretory potency as Loperamide in jejunum and colon.
參考文獻
Lavrijsen, K., et al.: Drug Metab. Dispos., 23, 354