(2S,3S)-2,3-二羥基丁二酸甲基(1R,4S)-4-氨基環戊-2-烯-1-甲酸叔丁酯

產品編號： LY-TRCM220435 純度：No Data Available CAS：419563-23-8

英文名稱：Methyl (1R,4S)-4-Amino-2-cyclopentene-1-carboxylate (2S,3S)-2,3-Dihydroxybutanedioic Acid

品牌：TRC

規格	目錄價格	上海	會員價格	數量
100mg	請詢價	0	一般3-5周，以TRC實際庫存為準	請詢價	- +

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基本信息

產品編號

LY-TRCM220435

CAS 號

419563-23-8

英文名稱

Methyl (1R,4S)-4-Amino-2-cyclopentene-1-carboxylate (2S,3S)-2,3-Dihydroxybutanedioic Acid

中文名稱

(2S,3S)-2,3-二羥基丁二酸甲基(1R,4S)-4-氨基環戊-2-烯-1-甲酸叔丁酯

分子式

C7H11NO2 . C4H6O6

分子量

291.26

純度

No Data Available

網頁展示純度為入庫指導純度值，各批次間存在一定差異，實際純度以收貨為準

MDL 號

類別

Building Blocks; Miscellaneous;

應用

Methyl (1R,4S)-4-Amino-2-cyclopentene-1-carboxylate (2S,3S)-2,3-Dihydroxybutanedioic Acid is an intermediate used in the synthesis of ent-Abacavir (A105015), which is an enatiomer of Abacavir (A105000). Abacavir is a carbocyclic 2'-deoxyguanosine nucleoside reverse transcriptase inhibitor and an anti-HIV drug used to treat HIV infection (1). Intracellular enzymes convert Abacavir to its active form, carbovir-triphosphate (CBV-TP), which then selectively inhibits HIV reverse transcriptase by incorporating into viral DNA (2). Abacavir is metabolized in the liver by uridine diphosphate glucuronyltransferase and alcohol dehydrogenase resulting in inactive glucuronide and carboxylate metabolites, respectively.