Standards; Pharmaceutical/API Drug Impurities/Metabolites;
應用
1-Hydroxy Ivabradine is an impurity of Ivabradine Hydrochloride(I940500); is a selective bradycardic agent with direct effect on the pacemaker If current of the sinoatrial node. Antianginal.
參考文獻
Thollon,C., et al.: Br. J. Pharmacol., 112, 37 (1994), Ragueneau, I., et al.: Clin. Pharmacol. Ther., 64, 192 (1998), Borer, J.S., et al.: Circulation, 107, 817 (2003), DiFrancesco, D., et al.: Drugs, 64, 1757 (2004),