Standards; Chiral Molecules; Molecular Biology; Pharmaceutical/API Drug Impurities/Metabolites;
應用
(αS)-α-[[2-(4-Morpholinyl)acetyl]amino]benzenebutanoyl-L-leucyl-N-[(1S)-3-methyl-1-(2-methylpropyl)-2-oxo-3-buten-1-yl]-L-phenylalaninamide is an impurity/intermediate in the preparation of Carfilzomib (C183460), which is a second-generation proteasome inhibitor that is used as a treatment in relapsed and refractory multiple myeloma.
參考文獻
Hoeferl-Prantz, K. & Wilhelm, T.: PCT Int. Appl. 104pp. Patent (2015) CODEN:PIXXD2; Pullagurla, M., et. al.: PCT Int. Appl. 27 pp. Patent (2016) CODEN:PIXXD2; Fostier, K., et al.: Oncotargets. Therap., 5, 237 (2012); Geurink, P.P., et al.: J. Med. Chem., 56, 1262 (2013); McCormack, P.L., et al.: Drugs., 72, 2023 (2012);
滬ICP備17019645號
400-821-0725
